Project description DEENESFRITPL A smart way to predict neurological disease progression AI systems can be used to develop models able to predict the progression of multiple sclerosis and amyotrophic lateral sclerosis. While both are very complex, chronic and progressive degenerative neurological diseases, their clinical evolution, prognosis and therapies are different. In this context, the EU-funded BRAINTEASER project will develop a system of wearable sensors to enable prediction and advance clinical decision-making and prevention. Specifically, software and apps will be designed to embrace an agile and user-centred design approach, accounting for the technical, medical, psychological and societal needs of the specific users. One main aim is to assist clinicians in suggesting interventions that can delay the progression of the disease. Show the project objective Hide the project objective Objective Amyotrophic Lateral Sclerosis (ALS) and Multiple Sclerosis (MS) are chronic diseases characterized by progressive or alternate impairment of neurological functions (motor, sensory, visual, cognitive). Patients have to manage alternated periods in hospital with care at home, experiencing a constant uncertainty regarding the timing of the disease acute phases and facing a considerable psychological and economic burden that also involves their caregivers. Clinicians, on the other hand, need tools able to support them in all the phases of the patient treatment, suggest personalized therapeutic decisions, indicate urgently needed interventions.Artificial Intelligence is the key to successfully satisfy these needs to: i) better describe disease mechanisms; ii) stratify patients according to their phenotype assessed all over the disease evolution; iii) predict disease progression in a probabilistic, time dependent fashion; iv) investigate the role of the environment; v) suggest interventions that can delay the progression of the disease.BRAINTEASER will integrate large clinical datasets with novel personal and environmental data collected using low-cost sensors and apps. Software and mobile apps will be designed embracing an agile and user-centred design approach, accounting for the technical, medical, psychological and societal needs of the specific users.BRAINTEASER will implement a system able to guarantee cybersecurity and data ownership to the patients; will provide quantitative evidence of benefits and effectiveness of using AI in health-care pathways implementing a proof-of-concept of its use in real clinical setting. Procedural requirements that support Software as Medical Device certification will be used involving clinicians and patients stakeholders and producing a set of recommendations for public health authorities. Results will be disseminated accordingly to an open science paradigm under the European Open Science Cloud initiative. Fields of science natural sciencescomputer and information sciencesartificial intelligencenatural sciencescomputer and information sciencessoftwaremedical and health scienceshealth sciencespublic healthmedical and health sciencesbasic medicineneurologymultiple sclerosismedical and health sciencesbasic medicineneurologyamyotrophic lateral sclerosis Keywords Open science data FAIRness AI personalized healthcare decision support systems quality healthcare at home societal equality risk detection prevention environmental exposure wearables Programme(s) H2020-EU.3.1. - SOCIETAL CHALLENGES - Health, demographic change and well-being Main Programme H2020-EU.3.1.4.2. - Individual awareness and empowerment for self-management of health Topic(s) SC1-DTH-02-2020 - Personalised early risk prediction, prevention and intervention based on Artificial Intelligence and Big Data technologies Call for proposal H2020-SC1-DTH-2018-2020 See other projects for this call Sub call H2020-SC1-DTH-2020-1 Funding Scheme RIA - Research and Innovation action Coordinator UNIVERSIDAD POLITECNICA DE MADRID Net EU contribution € 680 000,00 Address CALLE RAMIRO DE MAEZTU 7 EDIFICIO RECTORADO 28040 Madrid Spain See on map Region Comunidad de Madrid Comunidad de Madrid Madrid Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 680 000,00 Participants (13) Sort alphabetically Sort by Net EU contribution Expand all Collapse all UNIVERSITA DEGLI STUDI DI PADOVA Italy Net EU contribution € 732 250,00 Address VIA 8 FEBBRAIO 2 35122 Padova See on map Region Nord-Est Veneto Padova Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 732 250,00 FCIENCIAS.ID - ASSOCIACAO PARA A INVESTIGACAO E DESENVOLVIMENTO DE CIENCIAS Portugal Net EU contribution € 358 750,00 Address CAMPO GRANDE, EDIFICIO C1, PISO 3 1749 016 Lisbon See on map Region Continente Área Metropolitana de Lisboa Área Metropolitana de Lisboa Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 439 375,00 Third-party Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure. FACULDADE DE CIENCIAS DA UNIVERSIDADE DE LISBOA Portugal Net EU contribution € 80 625,00 Address CAMPO GRANDE C5 PISO 3 1749-016 Lisboa See on map Region Continente Área Metropolitana de Lisboa Área Metropolitana de Lisboa Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 80 625,00 UNIVERSITA DEGLI STUDI DI TORINO Italy Net EU contribution € 698 750,00 Address VIA GIUSEPPE VERDI 8 10124 Torino See on map Region Nord-Ovest Piemonte Torino Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 698 750,00 INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES Portugal Net EU contribution € 362 565,00 Address AVENIDA PROF EGAS MONIZ 1649 028 Lisboa See on map Region Continente Área Metropolitana de Lisboa Área Metropolitana de Lisboa Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 362 565,00 SERVICIO MADRILENO DE SALUD Spain Net EU contribution € 558 125,00 Address Paseo De la Castellana, 280 28046 MADRID See on map Region Comunidad de Madrid Comunidad de Madrid Madrid Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 558 125,00 FONDAZIONE ISTITUTO NEUROLOGICO NAZIONALE CASIMIRO MONDINO Italy Net EU contribution € 503 125,00 Address Via Mondino 2 27100 Pavia See on map Region Nord-Ovest Lombardia Pavia Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 733 125,00 Third-party Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure. UNIVERSITA DEGLI STUDI DI PAVIA Italy Net EU contribution € 230 000,00 Address STRADA NUOVA 65 27100 Pavia See on map Region Nord-Ovest Lombardia Pavia Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 230 000,00 PREDUZECE ZA INFORMACIONE TEHNOLOGIJE I ELEKTRONSKO TRGOVANJE BELIT DOO Serbia Net EU contribution € 456 875,00 Address TRG NIKOLE PASICA 9 11000 Beograd See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Србија - север Београдски регион Београдска област Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 456 875,00 INSILICOTRIALS TECHNOLOGIES S.P.A. Italy Net EU contribution € 500 270,00 Address RIVA GRUMULA 2 34123 Trieste See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Nord-Est Friuli-Venezia Giulia Trieste Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 551 750,00 Third-party Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure. INSILICOTRIALS TECHNOLOGIES BV Netherlands Net EU contribution € 51 480,00 Address BRUISTENSINGEL 130 5232 AC 'S-Hertogenbosch See on map Region Zuid-Nederland Noord-Brabant Noordoost-Noord-Brabant Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 51 480,00 ECHALLIANCE COMPANY LIMITED BY GUARANTEE Ireland Net EU contribution € 478 000,00 Address 20 HARCOURT STREET RAHENY D02H364 DUBLIN See on map Region Ireland Eastern and Midland Dublin Activity type Other Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 478 000,00 THE EUROPEAN BRAIN COUNCIL AISBL Belgium Net EU contribution € 198 375,00 Address RUE D EGMONT 11 1000 Bruxelles / Brussel See on map Region Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad Activity type Other Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 198 375,00
